The Problem
Patients exposed to toxic microbes
- Bacterial
- Fungal
- Virus
Hospital acquired infections on the rise
The Solution
A new class of antimicrobial complexes
US Patent 9,814,239 awarded, combining
- Commercially available water-soluble cationic biocides (e.g.PMBH)
- Water soluble anionic biocide (e.g. Omadine)
Combination complex PMBH.OM has different physical property
- Effective against bacteria, fungi and virus
- Suitable for incorporation into plastics
Process 1
The patented compounds (complexes) combine two conventional active antimicrobial components.
The structures of the complexes formed were characterized by NMR spectrometer. Example of many such complexes.
Why it works
- The cation and anion biocides are effective against different organisms.
- For example, the cation biocide PHMB (Vantocil 100) is extremely effective against gram positive and gram negative bacteria, and the anion biocide sodium omadine is extremely effective against fungus.
- We believe the obtained PHMB.Om has broader and better antimicrobial activities.
- The non-water soluble physical property will make it the best candidate for an antimicrobial additive of medical polymers.
Antifungal: Agar Plate G. Trabeum Growth Diameter
This digram indicate PHMB.Om has the best activities, has lowest growth at 10 ppm, no growth at 100 and 1000 ppm
Readings were taken after 4, 8, 12 and 14 days.
The 14-day results were recorded in centimeters (cm) of fungal growth
from center of the inoculated plug on the plate:
The Test results through EPA from USDA-FS-FPL (USDA- Forest Service- Forest Products Laboratory),
Antifungal: Agar Plate C. Versicolor Growth Diameter
This digram indicate CHxOm has the best activities, no growth at 10 ppm and 100 ppm
Readings were taken after 4, 8, 12 and 14 days.
The 14-day results were recorded in centimeters (cm) of fungal growth
from center of the inoculated plug on the plate:
The Test results through EPA from USDA-FS-FPL (USDA- Forest Service- Forest Products Laboratory),
Anti-Fungi Result summary
The Test results through EPA from USDA-FS-FPL (USDA- Forest Service- Forest Products Laboratory), against white rote and brown rote indicate:
Formed complex CHxOm and PHMB.Om both have better performance than control Chlorhexidine hydrochloride, PHMB, and Omadine.
Against Herpes Virus Effective Concentration
This digram indicate Mayly Compound 05 and 07 have better performance than consumer product, less chemicals required for effective results
This test results through NIAID, from Department of Pediatrics, University of Alabama School of Medicine
Explanation of Against Herpes Virus Effective Concentration
The control is the commercial product
The formed complexes have better activity than control
What this means
Less chemical needed for desired antimicrobial property
Less influence on polymer plastics physical influence
Broader coverage of microbials
Against Flu Virus Effective Concentration
