The Solution

The Problem

Patients exposed to toxic microbes

- Bacterial
- Fungal
- Virus

Hospital acquired infections on the rise

The Solution

A new class of antimicrobial complexes

US Patent 9,814,239 awarded, combining

  • Commercially available water-soluble cationic biocides (e.g.PMBH)
  • Water soluble anionic biocide (e.g. Omadine)

Combination complex PMBH.OM has different physical property

  • Effective against bacteria, fungi and virus
  • Suitable for incorporation into plastics

Process 1

The patented compounds (complexes) combine two conventional active antimicrobial components.
The structures of the complexes formed were characterized by NMR spectrometer. Example of many such complexes.

Why it works


  • The cation and anion biocides are effective against different organisms.
  • For example, the cation biocide PHMB (Vantocil 100) is extremely effective against gram positive and gram negative bacteria, and the anion biocide sodium omadine is extremely effective against fungus.
  • We believe the obtained PHMB.Om has broader and better antimicrobial activities.
  • The non-water soluble physical property will make it the best candidate for an antimicrobial additive of medical polymers.

Antifungal: Agar Plate G. Trabeum Growth Diameter

Antifungal-Agar-Plate-G.-Trabeum-Growth-Diameter

This digram indicate PHMB.Om has the best activities, has lowest growth at 10 ppm, no growth at 100 and 1000 ppm

Readings were taken after 4, 8, 12 and 14 days.
The 14-day results were recorded in centimeters (cm) of fungal growth from center of the inoculated plug on the plate:


The Test results through EPA from USDA-FS-FPL (USDA- Forest Service- Forest Products Laboratory),

Antifungal: Agar Plate C. Versicolor Growth Diameter

Antifungal-Agar-Plate-G.-Trabeum-Growth-Diameter

This digram indicate CHxOm has the best activities, no growth at 10 ppm and 100 ppm

Readings were taken after 4, 8, 12 and 14 days.
The 14-day results were recorded in centimeters (cm) of fungal growth from center of the inoculated plug on the plate:


The Test results through EPA from USDA-FS-FPL (USDA- Forest Service- Forest Products Laboratory),

Anti-Fungi Result summary

The Test results through EPA from USDA-FS-FPL (USDA- Forest Service- Forest Products Laboratory), against white rote and brown rote indicate:


Formed complex CHxOm and PHMB.Om both have better performance than control Chlorhexidine hydrochloride, PHMB, and Omadine.

Against Herpes Virus Effective Concentration

Antifungal-Agar-Plate-G.-Trabeum-Growth-Diameter

This digram indicate Mayly Compound 05 and 07 have better performance than consumer product, less chemicals required for effective results


 

This test results through NIAID, from Department of Pediatrics, University of Alabama School of Medicine

Explanation of Against Herpes Virus Effective Concentration

  • The control is the commercial product

  • The formed complexes have better activity than control

What this means

  • Less chemical needed for desired antimicrobial property

  • Less influence on polymer plastics physical influence

  • Broader coverage of microbials

Against Flu Virus Effective Concentration

Against-Flu-Virus-Effective-Concentration

This results indicate less materials of mayly compounds 7 & 8 needed to be active compare with controls.